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Immunological basis of the development of necrotic lesions following Mycobacterium avium infection by Manuela Flórido; Andrea M. Cooper; Rui Appelberg is a Immunology and Microbiology article available to read on EtoBox.

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## Summary Normal C57BL/6 mice infected with 10^6^ colony‐forming units of a highly virulent strain of __Mycobacterium avium__ developed a progressive infection characterized by loss of T cells from the tissues and infiltration with high numbers of heavily infected macrophages. In contrast, when C57BL/6 mice were infected with 10^2^ colony‐forming units of the same strain they retained T cells and T‐cell reactivity in the tissues, and granulomas evolved into large masses that, at 4 months of infection, exhibited central necrosis. The development of these necrotic lesions did not occur in nude mice, nor in mice genetically deficient in CD4, interleukin‐12 (IL‐12) p40, interferon‐γ (IFN‐γ) and CD40 and were reduced in mice deficient in CD54 or IL‐6. They were less numerous but bigger in mice deficient in IL‐10 or the inducible nitric oxide synthase, correlating with the increased resistance to mycobacterial proliferation of these strains as compared to control mice. The appearance of necrosis was not affected in mice deficient in CD8α, T‐cell receptor δ, tumour necrosis factor receptor p55, and perforin, nor was it affected in mice over‐expressing bcl2. The appearance of necrosis cou

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Author

Manuela Flórido; Andrea M. Cooper; Rui Appelberg

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0019-2805)

Published

2002

Language

EN

Field

Immunology and Microbiology (Life Sciences)