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Age‐related Changes in Hypothalamic Androgen Receptor and Estrogen Receptor α in Male Rats by Di Wu; Grace Lin; Andrea C. Gore is a Neuroscience article available to read on EtoBox.

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## Abstract The control of reproductive function involves actions of sex steroids upon their nuclear receptors in the hypothalamus and preoptic area (POA). Whether hypothalamic hormone receptors change their expression in aging male mammals has not been extensively pursued, although such changes may underlie functional losses in reproductive physiology occurring with aging. We performed a stereologic analysis of immunoreactive androgen receptor (AR) and estrogen receptor alpha (ERα) cells in three POA nuclei of male Sprague‐Dawley rats (anteroventral periventricular nucleus [AVPV], median preoptic area [MePO], and medial preoptic nucleus [MPN]), at young (3 months), middle‐aged (12 months), and old (20 months) ages. Serum testosterone and estradiol levels were assayed. Testosterone concentrations decreased significantly and progressively with aging. Estradiol concentrations were significantly higher in middle‐aged than either young or old rats. Stereologic analyses of the POA demonstrated that AR‐immunoreactive cell numbers and density in the AVPV, MePO, and MPN were significantly higher in old compared with young or middle‐aged rats. No change in the total number or density of ERα

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Author

Di Wu; Grace Lin; Andrea C. Gore

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0021-9967)

Published

2008

Language

EN

Field

Neuroscience (Life Sciences)