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SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation by Julia Ghelman; Laureen Grewing; Farina Windener; Stefanie Albrecht; Alexander Zarbock; Tanja Kuhlmann is a Neuroscience article available to read on EtoBox.

What is SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation about?

## Abstract Oligodendroglial progenitor cells (OPCs) are highly proliferative and migratory cells, which differentiate into complex myelin forming and axon ensheathing mature oligodendrocytes during myelination. Recent studies indicate that the oligodendroglial cell population is heterogeneous on transcriptional and functional level depending on the location in the central nervous system. Here, we compared intrinsic properties of OPC from spinal cord and brain on functional and transcriptional level. Spinal cord OPC demonstrated increased migration as well as differentiation capacity. Moreover, transcriptome analysis revealed differential expression of several genes between both OPC populations. In spinal cord OPC, we confirmed upregulation of SKAP2, a cytoplasmatic adaptor protein known for its implication in cytoskeletal remodeling and migration in other cell types. Recent findings suggest that actin dynamics determine not only oligodendroglial migration, but also differentiation: Whereas actin polymerization is important for process extension, actin destabilization and depolymerization is required for myelin sheath formation. Downregulation or complete lack of SKAP2 in OPC resul

Who reads SKAP2 as a new regulator of oligodendroglial migration and myelin sheath formation?

Author

Julia Ghelman; Laureen Grewing; Farina Windener; Stefanie Albrecht; Alexander Zarbock; Tanja Kuhlmann

Publisher

Wiley

Published

2021

Language

EN

Field

Neuroscience (Life Sciences)