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An LCN2‐Dependent Positive‐Feedback Loop Between Gastric Cancer Cells and Tumor‐Associated‐Macrophages Mediates Lymphangiogenesis and Lymphatic Metastasis by Zhixin Huang, Ying Li, Yan Qian, Linying Ye, Tianhao Zhang, Yang Cheng, Jialin Wu, is a nonfiction available to read on EtoBox.
What is An LCN2‐Dependent Positive‐Feedback Loop Between Gastric Cancer Cells and Tumor‐Associated‐Macrophages Mediates Lymphangiogenesis and Lymphatic Metastasis about?
Lymph node (LN) metastasis is a major determinant of poor prognosis inpatients with gastric cancer (GC). Tumor-associated macrophages (TAMs)play a crucial role in promoting tumor metastasis and progression; however,the underlying mechanisms through which TAMs induce LN metastasis in GCremain poorly understood. This study demonstrates that low lipocalin-2(LCN2) expression is associated with increased LN metastasis and shortersurvival in GC. Functionally, LCN2 silencing significantly increases M2-typeTAM infiltration, lymphangiogenesis, and LN metastasis. Mechanistically,LCN2 downregulates the NF-κB pathway-mediated CCL5 expression byinteracting with Annexin A1, which inhibits K63- and M1-linked ubiquitinationof NEMO. Furthermore, LCN2-regulated CCL5 recruits and repolarizes TAMsthrough the CCR5/PI3K/AKT/GSK3β axis, which subsequently promoteslymphangiogenesis and LN metastasis via vascular endothelial growth factorC (VEGFC) secretion. Additionally, interleukin-10 (IL-10) derived from M2-typeTAMs suppresses IκBζ and its target gene, LCN2, in GC cells by promotingIκBζ degradation, thereby establishing an IL-10/IκBζ/LCN2 positive-feedbackloop that sustains LCN2 suppression. These findi
Who reads An LCN2‐Dependent Positive‐Feedback Loop Between Gastric Cancer Cells and Tumor‐Associated‐Macrophages Mediates Lymphangiogenesis and Lymphatic Metastasis?
It is typically read by self-directed learners exploring a subject in depth.
Common subject areas: history, science, philosophy, social sciences.
- Author
- Zhixin Huang, Ying Li, Yan Qian, Linying Ye, Tianhao Zhang, Yang Cheng, Jialin Wu,
- Published
- 2025
- Language
- EN
- Category
- nonfiction
- Subjects
- Medical, Oncology, Medicine