Opening book details…
Can I read Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas on EtoBox?
Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas by Ping Yang; Thomas M. Kollmeyer; Kristin Buckner; William Bamlet; Karla V. Ballman; Robert B. Jenkins is a Medicine article available to read on EtoBox.
What is Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas about?
## Abstract ## BACKGROUND Deletions of 19q have been associated with gliomas, especially oligodendrogliomas. In addition, cases with oligodendrogliomas with the 19q deletion have been observed to have a better survival compared with cases without the 19q deletion. The authors have previously described a 150‐kilobase minimal deletion region in gliomas that maps to 19q13.33 and contains 3 novel candidate genes (__GLTSCR1__, __EHD2__, and __GLTSCR2__). ## METHODS The authors performed an association study using 141 cases with gliomas (61 cases with astrocytomas, 40 cases with oligodendrogliomas, 40 cases with mixed oligoastrocytomas) and 108 general controls. They evaluated 7 single nucleotide polymorphisms (SNPs) in 6 genes within and nearby the minimal 19q deletion region (__ERCC2__, __RAI__, __ASE‐1__, __ERCC1__, __GLTSCR1__, and __LIG1__). ## RESULTS The prevalence of a germline __GLTSCR1__‐exon‐1 T allele (SNP rs1035938) was 40% in cases with oligodendrogliomas compared with 27% in controls (__P__ = 0.029), and the prevalence of an ERCC2‐exon‐22 T allele (SNP rs1052555) was 35% in cases with oligodendrogliomas compared with 18% in controls (__P__ = 0.043). One high‐risk and 1 low
Who reads Polymorphisms in GLTSCR1 and ERCC2 are associated with the development of oligodendrogliomas?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ping Yang; Thomas M. Kollmeyer; Kristin Buckner; William Bamlet; Karla V. Ballman; Robert B. Jenkins
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)