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Resveratrol improves cardiac function and exercise performance in MI-induced heart failure through the inhibition of cardiotoxic HETE metabolites by Nobutoshi Matsumura; Shingo Takahara; Zaid H. Maayah; Nirmal Parajuli; Nikole J. Byrne; Sherif M. Shoieb; Carrie-Lynn M. Soltys; Donna L. Beker; Grant Masson; Ayman O.S. El-Kadi; Jason R.B. Dyck is a Medicine article available to read on EtoBox.
What is Resveratrol improves cardiac function and exercise performance in MI-induced heart failure through the inhibition of cardiotoxic HETE metabolites about?
Numerous epidemiological studies have demonstrated that approximately 40% of myocardial infarctions (MI) are associated with heart failure (HF). Resveratrol, a naturally occurring polyphenol, has been shown to be beneficial in the treatment of MI-induced HF in rodent models. However, the mechanism responsible for the effects of resveratrol are poorly understood. Interestingly, resveratrol is known to inhibit cytochrome P450 1B1 (CYP1B1) which is involved in the formation of cardiotoxic hydroxyeicosatetraenoic acid (HETE) metabolites. Therefore, we investigated whether resveratrol could improve MI-induced cardiac remodeling and HF in rats through the inhibition of CYP1B1 and its metabolites. To do this, rats were subjected to either sham surgery or a surgery to ligate the left anterior descending artery to induce a MI and subsequent HF. Three weeks post-surgery, rats with established HF were treated with control diet or administered a diet containing low dose of resveratrol. Our results showed that low dose resveratrol treatment significantly improves % ejection fraction in MI rats and reduces MI-induced left ventricular and atrial remodeling. Furthermore, non-cardiac symptoms of HF
Who reads Resveratrol improves cardiac function and exercise performance in MI-induced heart failure through the inhibition of cardiotoxic HETE metabolites?
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- Author
- Nobutoshi Matsumura; Shingo Takahara; Zaid H. Maayah; Nirmal Parajuli; Nikole J. Byrne; Sherif M. Shoieb; Carrie-Lynn M. Soltys; Donna L. Beker; Grant Masson; Ayman O.S. El-Kadi; Jason R.B. Dyck
- Publisher
- Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 0022-2828)
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)