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Inhibitory Activities of Grape Bioactive Compounds Against Enzymes Linked with Human Diseases by Vagish Dwibedi; Sahil Jain; Divya Singhal; Anuradha Mittal; Santosh Kumar Rath; Sanjai Saxena is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Inhibitory Activities of Grape Bioactive Compounds Against Enzymes Linked with Human Diseases about?
A quest for identification of novel, safe and efficient natural compounds, as additives in the modern food and cosmetic industries, has been prompted by concerns about toxicity and side effects of synthetic products. Plant phenolic compounds are one of the most documented natural products due to their multifarious biological applications. Grape (Vitis vinifera) is an important source of phenolic compounds such as phenolic acids, tannins, quinones, coumarins and, most importantly, flavonoids/flavones. This review crisply encapsulates enzyme inhibitory activities of various grape polyphenols towards different key human-ailment-associated enzymes: xanthine oxidase (gout), tyrosinase (hyperpigmentation), α-amylase and α-glucosidase (diabetes mellitus), pancreatic lipase (obesity), cholinesterase (Alzheimer's disease), angiotensin i-converting enzymes (hypertension), α-synuclein (Parkinson's disease) and histone deacetylase (various diseases). The review also depicts the enzyme inhibitory mechanism of various grape polyphenols and briefly discusses their stature as potential therapeutic and drug development candidates. ## Key points • Nineteen major bioactive polyphenols from the grape/
Who reads Inhibitory Activities of Grape Bioactive Compounds Against Enzymes Linked with Human Diseases?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Vagish Dwibedi; Sahil Jain; Divya Singhal; Anuradha Mittal; Santosh Kumar Rath; Sanjai Saxena
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)