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Can I read Systematic Review: the Association Between the Gut Microbiota and Medical Therapies in Inflammatory Bowel Disease on EtoBox?
Systematic Review: the Association Between the Gut Microbiota and Medical Therapies in Inflammatory Bowel Disease by Shiva T. Radhakrishnan; James L. Alexander; Benjamin H. Mullish; Kate I. Gallagher; Nick Powell; Lucy C. Hicks; Ailsa L. Hart; Jia V. Li; Julian R. Marchesi; Horace R. T. Williams is a Medicine article available to read on EtoBox.
What is Systematic Review: the Association Between the Gut Microbiota and Medical Therapies in Inflammatory Bowel Disease about?
## Summary ## Background The gut microbiota has been implicated in the pathogenesis of inflammatory bowel disease (IBD), with Faecalibacterium prausnitizii associated with protection, and certain genera (including Shigella and Escherichia) associated with adverse features. The variability of patient response to medical therapies in IBD is incompletely understood. Given the recognised contribution of the microbiota to treatment efficacy in other conditions, there may be interplay between the gut microbiota, IBD medical therapy and IBD phenotype. ## Aims To evaluate the bidirectional relationship between IBD medical therapies and the gut microbiota. ## Methods We conducted a systematic search of MEDLINE and EMBASE. All original studies analysing interactions between the gut microbiota and established IBD medical therapies were included. ## Results We screened 1296 records; 19 studies were eligible. There was heterogeneity in terms of sample analysis, treatment protocols, and outcome reporting. Increased baseline α‐diversity was observed in responders versus non‐responders treated with exclusive enteral nutrition (EEN), infliximab, ustekinumab or vedolizumab. Higher baseline Faecaliba
Who reads Systematic Review: the Association Between the Gut Microbiota and Medical Therapies in Inflammatory Bowel Disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shiva T. Radhakrishnan; James L. Alexander; Benjamin H. Mullish; Kate I. Gallagher; Nick Powell; Lucy C. Hicks; Ailsa L. Hart; Jia V. Li; Julian R. Marchesi; Horace R. T. Williams
- Publisher
- Wiley
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)