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Effect of beta-blockers on QT dynamics in the long QT syndrome: measuring the benefit by Matthew T. Bennett; Lorne J. Gula; George J. Klein; Allan C. Skanes; Raymond Yee; Peter Leong-Sit; Ishvinder Chattha; Raymond Sy; Douglas L. Jones; Andrew D. Krahn is a Medicine article available to read on EtoBox.
What is Effect of beta-blockers on QT dynamics in the long QT syndrome: measuring the benefit about?
## Aims: Beta-blockers are the standard of care for the treatment of long qt syndrome (lqts), and have been shown to reduce recurrent syncope and mortality in patients with type 1 lqts (lqt1). although beta-blockers have minimal effect on the resting corrected qt interval, their effect on the dynamics of the non-corrected qt interval is unknown, and may provide insight into their protective effects. ## Methods and results: Twenty-three patients from eight families with genetically distinct mutations for lqt1 performed exercise stress testing before and after beta-blockade. one hundred and fifty-two qt, qtc, and tpeak-tend intervals were measured before starting beta-blockers and compared with those at matched identical cycle lengths following beta-blockade. beta-blockers demonstrated heart-rate-dependent effects on the qt and qtc intervals. in the slowest heart rate tertile ( 100 b.p.m.), the use of beta-blocker was associated with a reduction in both the qt and qtc intervals (qt: 367 vs. 358 ms; p < 0.0001; qtc: 500 vs. 486 ms; p < 0.0001). the tpeak-tend interval showed minimal change at slower heart rates ( 100 b.p.m.) (87 vs. 84 ms; p = ns) following beta-blockade. ## Conclusio
Who reads Effect of beta-blockers on QT dynamics in the long QT syndrome: measuring the benefit?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Matthew T. Bennett; Lorne J. Gula; George J. Klein; Allan C. Skanes; Raymond Yee; Peter Leong-Sit; Ishvinder Chattha; Raymond Sy; Douglas L. Jones; Andrew D. Krahn
- Publisher
- Oxford University Press (OUP)
- Published
- 2014
- Language
- EN
- Field
- Medicine (Health Sciences)