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Puumala hantavirus genetic variability in an endemic region (Northern Sweden) by Patrik Johansson; Gert E. Olsson; Hwee-Teng Low; Göran Bucht; Clas Ahlm; Per Juto; Fredrik Elgh is a Medicine article available to read on EtoBox.

What is Puumala hantavirus genetic variability in an endemic region (Northern Sweden) about?

Puumala hantavirus (PUUV), naturally harboured and shed by bank voles (Myodes [Clethrionomys] glareolus), is the etiological agent to nephropathia epidemica (NE), a mild haemorrhagic fever with renal syndrome. Both host and virus are found throughout much of the European continent and in northern Sweden NE is the second most prevalent serious febrile viral infection after influenza. The reliability of diagnostics by PCR depends on genetic variability for the detection of viral nucleic acids in unknown samples. In the present study we evaluated the genetic variability of PUUV isolated from bank voles in an area of northern Sweden highly endemic for NE. Genetic variability among bank voles was also investigated to evaluate co-evolutionary patterns. We found that the viral sequence appeared stable across the 80km study region, with the exception of the southernmost sampling site, which differed from its nearest neighbour by 7%, despite a geographical separation of only 10km. The southernmost sampling site demonstrated a higher degree of genetic similarity to PUUV previously isolated 100km south thereof; two locations appear to constitute a separate PUUV phylogenetic branch. In contras

Who reads Puumala hantavirus genetic variability in an endemic region (Northern Sweden)?

Author

Patrik Johansson; Gert E. Olsson; Hwee-Teng Low; Göran Bucht; Clas Ahlm; Per Juto; Fredrik Elgh

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1567-1348)

Published

2008

Language

EN

Field

Medicine (Health Sciences)