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BSSB: BLAST Server for Structural Biologists by Muthukumarasamy Uthayakumar; Govindhan Sowmiya; Radhakrishnan Sabarinathan; N. Udayaprakash; M. Kirti Vaishnavi; Kanagaraj Sekar is a Materials Science article available to read on EtoBox.

What is BSSB: BLAST Server for Structural Biologists about?

The Basic Local Alignment Search Tool (__BLAST__) is one of the most widely used sequence alignment programs with which similarity searches, for both protein and nucleic acid sequences, can be performed against large databases at high speed. A large number of tools exist for processing__BLAST__output, but none of them provide three-dimensional structure visualization. This shortcoming has been addressed in the proposed tool__BLAST__Server for Structural Biologists (__BSSB__), which maps a__BLAST__output onto the three-dimensional structure of the subject protein. The three-dimensional structure of the subject protein is represented using a three-color coding scheme (identical: red; similar: yellow; and mismatch: white) based on the pairwise alignment obtained. Thus, the user will be able to visualize a possible three-dimensional structure for the query protein sequence. This information can be used to gain a deeper insight into the sequence–structure correlation. Furthermore, the additional structure-level information enables the user to make coherent and logical decisions regarding the type of input model structure or fragment that can be used for molecular replacement calculation

Who reads BSSB: BLAST Server for Structural Biologists?

Author

Muthukumarasamy Uthayakumar; Govindhan Sowmiya; Radhakrishnan Sabarinathan; N. Udayaprakash; M. Kirti Vaishnavi; Kanagaraj Sekar

Publisher

International Union of Crystallography; Blackwell Publishing Inc.; International Union of Crystallography (IUCr) (ISSN 0021-8898)

Published

2011

Language

EN

Field

Materials Science (Physical Sciences)