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2030 by A. Bouakaz; T.A. Tran; S. Roger; J.Y. Leguennec; F. Tranquart is a Medicine article available to read on EtoBox.

What is 2030 about?

amine nephron injury induced by GBCA activation with diagnostic ultrasound. Methods: Anesthetized hairless rats were scanned in a water bath using a diagnostic ultrasound system with 1.5 MHz probe. The probe was clamped to image the right kidney 4 cm away with a tissue mimicking phantom inserted between the probe and the rat. A dose of 10 L/kg of GBCA was diluted in saline and injected via tail vein. Ten single imaging frames were then triggered every 10 s at a measured MI of 1.6 (after the phantom). Results: When the kidney was removed within 5 minutes, a band of blood-filled nephrons was visible on the surface of the kidney. Histological examination revealed blood-filled glomerulus and proximal convoluted tubules. Proteinuria, hematuria and detached podocytes were detected in urine samples collected four hours after imaging. In 24 hr kidney samples, some tubules remained packed with blood cells and the epithelial lining of the tubules appeared to be injured. Similar results were obtained using a single imaging frame. Conclusions: GBCA activated by diagnostic ultrasound in rats caused potentially irreversible injury to entire nephrons under conditions simulating clinical use.

Who reads 2030?

Author

A. Bouakaz; T.A. Tran; S. Roger; J.Y. Leguennec; F. Tranquart

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0301-5629)

Published

2006

Language

JA

Field

Medicine (Health Sciences)