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Intrarenal Angiotensin and Bradykinin Peptide Levels in the Remnant Kidney Model of Renal Insufficiency by Fiona E. Mackie; Duncan J. Campbell; Timothy W. Meyer is a Medicine article available to read on EtoBox.

What is Intrarenal Angiotensin and Bradykinin Peptide Levels in the Remnant Kidney Model of Renal Insufficiency about?

## Background: The remnant kidney model of renal failure is associated with normal or suppressed plasma renin and angiotensin (ang) ii levels when hypertension is established. however, the hypertension responds to angiotensin-converting enzyme (ace) inhibition and ang ii receptor antagonism, suggesting a role for ang ii in the hypertensive process. bradykinin (bk) is a potent vasoactive peptide that may also participate in this model. ## Methods: Ang ii and bk peptides were measured in the ischemic peri-infarct portion and the intact portion of the remnant kidney at two, five, and seven weeks after surgery. plasma ang ii, renin, angiotensinogen, and aldosterone levels were also measured. ## Results: Ang ii levels in the peri-infarct portion were higher than in the intact portion at all time points and were higher than in sham-operated kidney at two weeks. ang ii levels in the intact portion were similar to the levels in kidneys of sham-operated rats at two and five weeks and were suppressed at seven weeks. bk levels were increased in the peri-infarct portion at all time points and in the intact portion at two and five weeks. plasma ang ii and aldosterone levels were also elevated a

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Author

Fiona E. Mackie; Duncan J. Campbell; Timothy W. Meyer

Publisher

Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; ScienceOpen (ISSN 0085-2538)

Published

2001

Language

EN

Field

Medicine (Health Sciences)