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Can I read Linearly Divergent Treatment Effects in Clinical Trials with Repeated Measures: Efficient Analysis Using Summary Statistics on EtoBox?
Linearly Divergent Treatment Effects in Clinical Trials with Repeated Measures: Efficient Analysis Using Summary Statistics by Lars J. Frison; Stuart J. Pocock is a Mathematics article available to read on EtoBox.
What is Linearly Divergent Treatment Effects in Clinical Trials with Repeated Measures: Efficient Analysis Using Summary Statistics about?
In many randomized clinical trials with repeated measures of a response variable one anticipates a linear divergence over time in the difference between treatments. This paper explores how to make an efficient choice of analysis based on individual patient summary statistics. With the objective of estimating the mean rate of treatment divergence the simplest choice of summary statistic is the regression coefficient of response on time for each subject (SLOPE). The gains in statistical efficiency imposed by adjusting for the observed pre-treatment levels, or even better the estimated intercepts, are clarified. In the process, we develop the optimal linear summary statistic for any repeated measures design with assumed known covariance structure and shape of true mean treatment difference over time. Statistical power considerations are explored and an example from an asthma trial is used to illustrate the main points.
Who reads Linearly Divergent Treatment Effects in Clinical Trials with Repeated Measures: Efficient Analysis Using Summary Statistics?
It is typically read by researchers, students, and practitioners in Mathematics.
- Author
- Lars J. Frison; Stuart J. Pocock
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0277-6715)
- Published
- 1998
- Language
- EN
- Field
- Mathematics (Physical Sciences)