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FT‐MS in the de novo top‐down sequencing of natural nontryptic peptides by Albert T. Lebedev; Irina D. Vasileva; Tatiana Y. Samgina is a Chemistry article available to read on EtoBox.

What is FT‐MS in the de novo top‐down sequencing of natural nontryptic peptides about?

The present review covers available results on the application of FT-MS for the de novo sequencing of natural peptides of various animals: cones, bees, snakes, amphibians, scorpions, and so forth. As these peptides are usually bioactive, the animals efficiently use them as a weapon against microorganisms or higher animals including predators. These peptides represent definite interest as drugs of future generations since the mechanism of their activity is completely different in comparison with that of the modern antibiotics. Utilization of those peptides as antibiotics can eliminate the problem of the bacterial resistance development. Sequence elucidation of these bioactive peptides becomes even more challenging when the species genome is not available and little is known about the protein origin and other properties of those peptides in the study. De novo sequencing may be the only option to obtain sequence information. The benefits of FT-MS for the top-down peptide sequencing, the general approaches of the de novxxo sequencing, the difficult cases involving sequence coverage, isobaric and isomeric amino acids, cyclization of short peptides, the presence of posttranslational modi

Who reads FT‐MS in the de novo top‐down sequencing of natural nontryptic peptides?

Author

Albert T. Lebedev; Irina D. Vasileva; Tatiana Y. Samgina

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0277-7037)

Published

2020

Language

EN

Field

Chemistry (Physical Sciences)