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2157. Low Interferon-γ and Interleukin-13 Levels in the Respiratory Tract are Related to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants. by Fausto M Ferolla; Analía Toledano; Ana Caratozzolo; Laura B Talarico; Patricio L Acosta; Graciela Theiler; Eduardo W Yfran; Javier Matute; Normando Mascardi; Pablo Neira; María M Contrini; Eduardo L López is a Medicine article available to read on EtoBox.

What is 2157. Low Interferon-γ and Interleukin-13 Levels in the Respiratory Tract are Related to Life-threatening Respiratory Syncytial Virus Infection in Previously Healthy Infants. about?

## Abstract ## Background The mechanisms of interindividual susceptibility to respiratory syncytial virus (RSV) are not clearly understood. Viral load (VL), an exaggerated immune response or T-helper 2 (Th2) bias were postulated as playing a role in the severity of RSV infection. We aimed to analyze VL, cytokine profiles and their association with life-threatening disease (LTD). ## Methods Prospective cohort study including previously healthy full-term infants < 12 months old, hospitalized with a first RSV infection in 2017-2019. Nasopharyngeal aspirates were performed on admission to assess VL (by qRT-PCR) and cytokines levels (using a Bioplex panel). Cytokines were grouped according to their functional classification: proinflammatory (TNF-α), regulatory (interleukin [IL]-10), Th1 (interfereron-γ [IFN-γ]), Th2 (IL-4, IL-5, IL-9, IL-13) and Th17 (IL-17a). Patients were defined to have LTD when required admittance to the intensive care units and ventilatory support. ## Results One hundred and nineteen patients were studied, 68 (57%) were male; median age was 3 months. Nineteen (16%) infants developed LTD, with no significant differences in socioeconomic, pregnancy and infant variabl

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Author

Fausto M Ferolla; Analía Toledano; Ana Caratozzolo; Laura B Talarico; Patricio L Acosta; Graciela Theiler; Eduardo W Yfran; Javier Matute; Normando Mascardi; Pablo Neira; María M Contrini; Eduardo L López

Publisher

Oxford University Press (OUP)

Published

2022

Language

EN

Field

Medicine (Health Sciences)