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Oxidative Stress Following Traumatic Brain Injury in Rats : Quantitation of Biomarkers and Detection of Free Radical Intermediates by Vladimir A. Tyurin; Yulia Y. Tyurina; Grigory G. Borisenko; Tatiana V. Sokolova; Vladimir B. Ritov; Peter J. Quinn; Marie Rose; Patrick Kochanek; Steven H. Graham; Valerian E. Kagan is a Neuroscience article available to read on EtoBox.
What is Oxidative Stress Following Traumatic Brain Injury in Rats : Quantitation of Biomarkers and Detection of Free Radical Intermediates about?
**Abstract:** Oxidative stress may contribute to many pathophysiologic changes that occur after traumatic brain injury. In the current study, contemporary methods of detecting oxidative stress were used in a rodent model of traumatic brain injury. The level of the stable product derived from peroxidation of arachidonyl residues in phospholipids, 8‐__epi__‐prostaglandin F~2α~, was increased at 6 and 24 h after traumatic brain injury. Furthermore, relative amounts of fluorescent end products of lipid peroxidation in brain extracts were increased at 6 and 24 h after trauma compared with sham‐operated controls. The total antioxidant reserves of brain homogenates and water‐soluble antioxidant reserves as well as tissue concentrations of ascorbate, GSH, and protein sulfhydryls were reduced after traumatic brain injury. A selective inhibitor of cyclooxygenase‐2, SC 58125, prevented depletion of ascorbate and thiols, the two major water‐soluble antioxidants in traumatized brain. Electron paramagnetic resonance (EPR) spectroscopy of rat cortex homogenates failed to detect any radical adducts with a spin trap, 5,5‐dimethyl‐1‐pyrroline __N__‐oxide, but did detect ascorbate radical signals. Th
Who reads Oxidative Stress Following Traumatic Brain Injury in Rats : Quantitation of Biomarkers and Detection of Free Radical Intermediates?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Vladimir A. Tyurin; Yulia Y. Tyurina; Grigory G. Borisenko; Tatiana V. Sokolova; Vladimir B. Ritov; Peter J. Quinn; Marie Rose; Patrick Kochanek; Steven H. Graham; Valerian E. Kagan
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 2002
- Language
- EN
- Field
- Neuroscience (Life Sciences)