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Lian et al. demonstrate that after two decades of antiretroviral therapy, intact HIV-1 proviruses are predominantly integrated in heterochromatin, influenced by immune selection mechanisms. This integration pattern suggests that such proviruses are less transcriptionally active and potentially less capable of causing viral rebound. The findings indicate that long-term ART may lead to a reservoir structure characterized by deep latency, impacting the ability to control HIV-1 upon treatment interruption.
- Author
- megren01
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- EN