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Can I read Anthracyclines in Haematology: Preclinical Studies, Toxicity and Delivery Systems on EtoBox?
Anthracyclines in Haematology: Preclinical Studies, Toxicity and Delivery Systems by D.S. Richardson; S.A. Johnson is a Medicine article available to read on EtoBox.
What is Anthracyclines in Haematology: Preclinical Studies, Toxicity and Delivery Systems about?
The anthracyclines are widely used in the treatment of haematological and non-haematological malignancy and there is now more than 30 years' clinical experience with these agents but despite this, their mechanism of action is incompletely understood. The anthracyclines have been shown to intercalate with DNA and indirectly inhibit the activity of the enzyme topoisomerase II, resulting in DNA strand breaks. More recently, workers have focused on induction of apoptosis and have shown that daunorubicin stimulates production of the apoptotic mediator, ceramide and that the activity of doxorubicin can be blocked by inhibitors of CD95 (fas). One of the major problems with anthracycline therapy is the development of resistance which may be mediated by p-glycoprotein or by other mechanisms. Much recent research has concentrated on methods to modulate the drugresistant phenotype and these include development of new analogues and use of specific reversal agents. The toxicity profile of the anthracyclines includes bone marrow suppression, severe local reaction following extravasation, radiation recall, alopecia, gastrointestinal and hepatic effects, development of secondary malignancies and s
Who reads Anthracyclines in Haematology: Preclinical Studies, Toxicity and Delivery Systems?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- D.S. Richardson; S.A. Johnson
- Publisher
- Elsevier Science; Elsevier ; Churchill Livingstone; Elsevier BV (ISSN 0268-960X)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)