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Features of Endoscopic Procedure Site Reaction Associated with a Recently Approved Submucosal Lifting Agent by Castrodad-Rodríguez, Carlos A.; Panarelli, Nicole C.; Gersten, Adam J.; Liu, Qiang; Feely, Michael; Jabbour, Tony El is a Medicine article available to read on EtoBox.
What is Features of Endoscopic Procedure Site Reaction Associated with a Recently Approved Submucosal Lifting Agent about?
Endoscopic resection techniques, such as endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD), are frequently aided by injection of submucosal lifting solutions that create a plane for dissection and protect deeper mural layers. ORISETM gel is a recently approved synthetic lifting solution that produces a localized inflammatory reaction associated with retained gel at the injection site. We describe a series of six cases of ORISETM-associated inflammatory lesions in patients who underwent endoscopic resections. Deposits comprised pale fibrillary or hyalinized eosinophilic material, depending on their age. All cases were associated with an inflammatory reaction composed of foreign-body giant cells and scattered eosinophils. ORISETM gel extended laterally and deeply beyond residual tumors in all cases. Histochemically, the material proved to be negative for Congo Red, and mucicarmine, faint blue with Alcian blue, but positive for PAS and PAS-D. It stained blue with trichrome. Such deposits were absent in cases, wherein other widely-available lifting solutions were used. We compared ORISETM deposits to histologically similar extracellular deposits, namely amyl
Who reads Features of Endoscopic Procedure Site Reaction Associated with a Recently Approved Submucosal Lifting Agent?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Castrodad-Rodríguez, Carlos A.; Panarelli, Nicole C.; Gersten, Adam J.; Liu, Qiang; Feely, Michael; Jabbour, Tony El
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)