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Vision Enhancement System for Detection of Oral Cavity Neoplasia Based on Autofluorescence by Ekaterina Svistun; Reza Alizadeh‐Naderi; Adel El‐Naggar; Rhonda Jacob; Ann Gillenwater; Rebecca Richards‐Kortum is a Medicine article available to read on EtoBox.
What is Vision Enhancement System for Detection of Oral Cavity Neoplasia Based on Autofluorescence about?
## Abstract ## Background. Early detection of squamous cell carcinoma (SCC) in the oral cavity can improve survival. It is often difficult to distinguish neoplastic and benign lesions with standard white light illumination. We evaluated whether a technique that capitalizes on an alternative source of contrast, tissue autofluorescence, improves visual examination. ## Methods. Autofluorescence of freshly resected oral tissue was observed visually and photographed at specific excitation/emission wavelength combinations optimized for response of the human visual system and tissue fluorescence properties. Perceived tumor margins were indicated for each wavelength combination. Punch biopsies were obtained from several sites from each specimen. Sensitivity and specificity were evaluated by correlating histopathologic diagnosis with visual impression. ## Results. Best results were achieved with illumination at 400 nm and observation at 530 nm. Here, sensitivity and specificity were 91% and 86% in discrimination of normal tissue from neoplasia. This compares favorably with white light examination, in which sensitivity and specificity were 75% and 43%. ## Conclusions. Oral cavity autofluores
Who reads Vision Enhancement System for Detection of Oral Cavity Neoplasia Based on Autofluorescence?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ekaterina Svistun; Reza Alizadeh‐Naderi; Adel El‐Naggar; Rhonda Jacob; Ann Gillenwater; Rebecca Richards‐Kortum
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1043-3074)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)