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Can I read Randomized trial comparing postoperative chemotherapy with vindesine and cisplatin plus thoracic irradiation with irradiation alone in stage III (N2) non‐small cell lung cancer on EtoBox?
Randomized trial comparing postoperative chemotherapy with vindesine and cisplatin plus thoracic irradiation with irradiation alone in stage III (N2) non‐small cell lung cancer by K. M. W. Pisters; M. G. Kris; R. J. Gralla; B. Hilaris; P. M. McCormack; M. S. Bains; N. Martini is a Medicine article available to read on EtoBox.
What is Randomized trial comparing postoperative chemotherapy with vindesine and cisplatin plus thoracic irradiation with irradiation alone in stage III (N2) non‐small cell lung cancer about?
This prospective randomized trial was performed to determine whether postoperative chemotherapy with vindesine and cisplatin could lengthen time to progression and overall survival in stage I11 (Tl-3N2MO) non-small cell lung cancer (NSCLC) patients. Seventy-two patients were entered; 36 were randomized to receive chemotherapy. Patients were stratified by extent of resection (complete vs. incomplete) and histology (squamous vs. nonsquamous). All had surgery and mediastinal irradiation 6 7 weeks post-thoracotomy . Incompletely resected patients had intraoperative Iz5I and/or 1921r implantation. Vindesine (3 mg/m2) weekly X 5 , then every 2 weeks X 8, and cisplatin (1 20 mg/m2) days 1, 29, 7 1, 1 13 were planned for those randomized to chemotherapy. No difference in time to progression (median 9.2 months for radiation + chemotherapy vs. 9.0 months for radiation, P = 0.35) or overall survival (16.3 months for radiation + chemotherapy vs. 19.1 months for radiation, P = 0.42) was found. Postoperative vindesine and cisplatin did not prolong time to progression or survival in this population of stage I11 NSCLC.
Who reads Randomized trial comparing postoperative chemotherapy with vindesine and cisplatin plus thoracic irradiation with irradiation alone in stage III (N2) non‐small cell lung cancer?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- K. M. W. Pisters; M. G. Kris; R. J. Gralla; B. Hilaris; P. M. McCormack; M. S. Bains; N. Martini
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-4790)
- Published
- 1994
- Language
- EN
- Field
- Medicine (Health Sciences)