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Raman spectroscopy for optical diagnosis in the larynx: Preliminary findings by David P. Lau; Zhiwei Huang; Harvey Lui; Donald W. Anderson; Ken Berean; Murray D. Morrison; Liang Shen; Haishan Zeng is a Medicine article available to read on EtoBox.

What is Raman spectroscopy for optical diagnosis in the larynx: Preliminary findings about?

Background and Objectives: Raman spectroscopy (RS) provides information about molecular structure and is a potential tool for non-invasive tissue diagnosis. To determine if Raman spectra could be obtained rapidly from laryngeal tissue in vitro, and compare Raman spectra from normal, benign, and cancerous laryngeal tissue. Study Design/Materials and Methods: Forty-seven laryngeal specimens were studied using RS with signal acquisition times (SAT) between 1 and 30 second(s). Multivariate analysis was used to determine the diagnostic ability of RS compared to standard histology (n 1⁄4 18, 13, and 16 respectively for normal tissue, carcinoma, and squamous papilloma). Results: Good quality spectra were obtained with 5-second SAT. Spectral peak analysis showed prediction sensitivities of 89%, 69%, and 88%, and specificities of 86%, 94%, and 94% for normal tissue, carcinoma, and papilloma. Conclusions: In the larynx, spectral differences appear to exist between normal tissue, carcinoma, and papilloma. The ability to obtain spectra rapidly supports potential for future in vivo studies.

Who reads Raman spectroscopy for optical diagnosis in the larynx: Preliminary findings?

Author

David P. Lau; Zhiwei Huang; Harvey Lui; Donald W. Anderson; Ken Berean; Murray D. Morrison; Liang Shen; Haishan Zeng

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0196-8092)

Published

2005

Language

EN

Field

Medicine (Health Sciences)