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Early or Late Bacterial Lung Infection Increases Mortality After Traumatic Brain Injury in Male Mice and Chronically Impairs Monocyte Innate Immune Function by Sarah J. Doran; Rebecca J. Henry; Kari Ann Shirey; James P. Barrett; Rodney M. Ritzel; Wendy Lai; Jorge C. Blanco; Alan I. Faden; Stefanie N. Vogel; David J. Loane is a Medicine article available to read on EtoBox.

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## Objectives: Respiratory infections in the postacute phase of traumatic brain injury impede optimal recovery and contribute substantially to overall morbidity and mortality. this study investigated bidirectional innate immune responses between the injured brain and lung, using a controlled cortical impact model followed by secondary streptococcus pneumoniae infection in mice. ## Design: Experimental study. ## Setting: Research laboratory. ## Subjects: Adult male c57bl/6j mice. ## Interventions: C57bl/6j mice were subjected to sham surgery or moderate-level controlled cortical impact and infected intranasally with s. pneumoniae (1,500 colony-forming units) or vehicle (phosphate-buffered saline) at 3 or 60 days post-injury. ## Main results: At 3 days post-injury, s. pneumoniae-infected traumatic brain injury mice (tbi + sp) had a 25% mortality rate, in contrast to no mortality in s. pneumoniae-infected sham (sham + sp) animals. tbi + sp mice infected 60 days post-injury had a 60% mortality compared with 5% mortality in sham + sp mice. in both studies, tbi + sp mice had poorer motor function recovery compared with tbi + pbs mice. there was increased expression of pro-inflammatory ma

Who reads Early or Late Bacterial Lung Infection Increases Mortality After Traumatic Brain Injury in Male Mice and Chronically Impairs Monocyte Innate Immune Function?

Author

Sarah J. Doran; Rebecca J. Henry; Kari Ann Shirey; James P. Barrett; Rodney M. Ritzel; Wendy Lai; Jorge C. Blanco; Alan I. Faden; Stefanie N. Vogel; David J. Loane

Publisher

Lippincott Williams and Wilkins; Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 0090-3493)

Published

2020

Language

EN

Field

Medicine (Health Sciences)