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Exchange-influenced T2ρ contrast in human brain images measured with adiabatic radio frequency pulses by Shalom Michaeli; Heidi Gröhn; Olli Gröhn; Dennis J. Sorce; Risto Kauppinen; Charles S. Springer Jr.; Kâmil Uğurbil; Michael Garwood is a Medicine article available to read on EtoBox.

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## Abstract Transverse relaxation in the rotating frame (__T__~2ρ~) is the dominant relaxation mechanism during an adiabatic Carr–Purcell (CP) spin‐echo pulse sequence when no delays are used between pulses in the CP train. The exchange‐induced and dipolar interaction contributions (__T__~2ρ,ex~ and __T__~2ρ,dd~) depend on the modulation functions of the adiabatic pulses used. In this work adiabatic pulses having different modulation functions were utilized to generate __T__~2ρ~ contrast in images of the human occipital lobe at magnetic field of 4 T. __T__~2ρ~ time constants were measured using an adiabatic CP pulse sequence followed by an imaging readout. For these measurements, adiabatic full passage pulses of the hyperbolic secant HS__n__ (__n__ = 1 or 4) family having significantly different amplitude—and frequency—modulation functions were used with no time delays between pulses. A dynamic averaging (DA) mechanism (e.g., chemical exchange and diffusion in the locally different magnetic susceptibilities) alone was insufficient to fully describe differences in brain tissue water proton __T__~2ρ~ time constants. Measurements of the apparent relaxation time constants (__T__) of br

Who reads Exchange-influenced T2ρ contrast in human brain images measured with adiabatic radio frequency pulses?

Author

Shalom Michaeli; Heidi Gröhn; Olli Gröhn; Dennis J. Sorce; Risto Kauppinen; Charles S. Springer Jr.; Kâmil Uğurbil; Michael Garwood

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2005

Language

EN

Field

Medicine (Health Sciences)