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In colorectal carcinoma patients, serum vitamin D levels vary according to stage of the carcinoma by Yaron Niv; Ami D. Sperber; Arie Figer; Dror Igael; Shraga Shany; Gerald Fraser; Betti Schwartz is a Medicine article available to read on EtoBox.
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BACKGROUND. Epidemiologic studies have demonstrated an inverse correlation between dietary calcium and vitamin D intake and the incidence of colorectal carcinoma. Elevated serum levels of 25-hydroxyvitamin D 3 (25-OH-D 3 ) are associated with a major reduction in the incidence of this neoplasm. The reduction in tumor size and number induced by calcium supplements in an experimental carcinogenesis model was neutralized by vitamin D 3 deficiency. To the authors' knowledge, vitamin D serum levels have never been determined previously in colorectal carcinoma patients. They compared serum 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), 25-OH-D 3 , and parathyroid hormone (PTH) levels of colorectal carcinoma patients with those of healthy controls. METHODS. Serum 1,25(OH) 2 D 3 , 25-OH-D 3 , and PTH levels were determined in 84 colorectal carcinoma patients (10 with Stage I, 29 with Stage II, 25 with Stage III, and 20 with Stage IV) and 30 healthy controls, all of whom were normocalcemic and not taking calcium or vitamin D supplements. RESULTS. 25-OH-D 3 serum levels were higher in cancer patients than controls, irrespective of stage. Serum 1,25(OH) 2 D 3 decreased with advancing stage: 73Ϯ
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- Author
- Yaron Niv; Ami D. Sperber; Arie Figer; Dror Igael; Shraga Shany; Gerald Fraser; Betti Schwartz
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)