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Can I read Water-stable Zirconium-based Metal-organic Frameworks Armed Polyvinyl Alcohol Nanofibrous Membrane with Enhanced Antibacterial Therapy for Wound Healing on EtoBox?
Water-stable Zirconium-based Metal-organic Frameworks Armed Polyvinyl Alcohol Nanofibrous Membrane with Enhanced Antibacterial Therapy for Wound Healing by Jie Zhu; Weiwang Qiu; Chengjian Yao; Chun Wang; Dequn Wu; Shravan Pradeep; Jianyong Yu; Zijian Dai is a Chemistry article available to read on EtoBox.
What is Water-stable Zirconium-based Metal-organic Frameworks Armed Polyvinyl Alcohol Nanofibrous Membrane with Enhanced Antibacterial Therapy for Wound Healing about?
Inadequate water-stability and antibacterial activity limit the biomedical application of polyvinyl alcohol (PVA)-based membranes in moist environments. In this work, we propose a strategy to improve the water-stability of PVA membranes via metal complexation and heat treatment. We report a simple routine where the zirconium-based UiO-66-NH metal-organic frameworks (MOFs) are nucleated as a layer on the surface of PVA nanofibrous membranes (UiO-66-NH@PVA NFMs). We find that the chemical modification of membranes increases their hydrophilicity and adds on mechanical support for the brittle UiO-66-NH MOFs. Additionally, we demonstrate the application of UiO-66-NH MOFs as drug carriers for antibacterial drug, levofloxacin (LV). The active drug component is preloaded during the one-step nucleation process. The obtained LV loaded UiO-66-NH@PVA NFMs (LV@UiO-66-NH@PVA) are shown to be bactericidal with the efficiency > 99.9% at 100 μg/mL against two bacterial species, Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Compared with the commercially available gauzes, the UiO-66-NH@PVA and LV@UiO-66-NH@PVA treatments will significantly improve the wound healing process. Anima
Who reads Water-stable Zirconium-based Metal-organic Frameworks Armed Polyvinyl Alcohol Nanofibrous Membrane with Enhanced Antibacterial Therapy for Wound Healing?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Jie Zhu; Weiwang Qiu; Chengjian Yao; Chun Wang; Dequn Wu; Shravan Pradeep; Jianyong Yu; Zijian Dai
- Published
- 2021
- Language
- EN
- Field
- Chemistry (Physical Sciences)