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Can I read Lipid-induced Transcriptomic Changes in Blood Link to Lipid Metabolism and Allergic Response on EtoBox?
Lipid-induced Transcriptomic Changes in Blood Link to Lipid Metabolism and Allergic Response by Koen F. Dekkers; Roderick C. Slieker; Andreea Ioan-Facsinay; Maarten van Iterson; M. Arfan Ikram; Marleen M. J. van Greevenbroek; Jan H. Veldink; Lude Franke; Dorret I. Boomsma; P. Eline Slagboom; J. Wouter Jukema; Bastiaan T. Heijmans; BIOS consortium is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Lipid-induced Transcriptomic Changes in Blood Link to Lipid Metabolism and Allergic Response about?
## Abstract Immune cell function can be altered by lipids in circulation, a process potentially relevant to lipid-associated inflammatory diseases including atherosclerosis and rheumatoid arthritis. To gain further insight in the molecular changes involved, we here perform a transcriptome-wide association analysis of blood triglycerides, HDL cholesterol, and LDL cholesterol in 3229 individuals, followed by a systematic bidirectional Mendelian randomization analysis to assess the direction of effects and control for pleiotropy. Triglycerides are found to induce transcriptional changes in 55 genes and HDL cholesterol in 5 genes. The function and cell-specific expression pattern of these genes implies that triglycerides downregulate both cellular lipid metabolism and, unexpectedly, allergic response. Indeed, a Mendelian randomization approach based on GWAS summary statistics indicates that several of these genes, including interleukin-4 (IL4) and IgE receptors (FCER1A, MS4A2), affect the incidence of allergic diseases. Our findings highlight the interplay between triglycerides and immune cells in allergic disease.
Who reads Lipid-induced Transcriptomic Changes in Blood Link to Lipid Metabolism and Allergic Response?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Koen F. Dekkers; Roderick C. Slieker; Andreea Ioan-Facsinay; Maarten van Iterson; M. Arfan Ikram; Marleen M. J. van Greevenbroek; Jan H. Veldink; Lude Franke; Dorret I. Boomsma; P. Eline Slagboom; J. Wouter Jukema; Bastiaan T. Heijmans; BIOS consortium
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)