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Nitric Oxide Is Involved in the Genesis of Pulsatile LHRH Secretion from Immortalized LHRH Neurons by Francisco José López; Marcelo Moretto; István Merchenthaler; Andrés Negro-Vilar is a Neuroscience article available to read on EtoBox.

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Neuronal networks controlling endocrine events present synchronous activity which is required for maintaining physiological functions, including reproduction. Although pulsatile hormone secretion is of paramount importance, the mechanism(s) by which secretory episodes are generated remain largely unknown. Nitric oxide (NO) has become the prototype of a new family of signaling molecules in the body. Nitric oxide diffuses from the source cell and controls activity of neighboring neurons as well as itself as a retrograde messenger. Cells of the luteinizing hormone‐releasing hormone (LHRH) neuronal network, the key component in the control of reproduction, are scattered and loosely arranged in the anterior hypothalamus. A diffusible neurotransmitter could provide a means for establishing synchronous activation of the LHRH neuronal network leading to physiologically‐relevant pulsatile LHRH secretion. In this study, we demonstrate that immortalized LHRH‐producing neurons (GT1–7 cells) express NO synthase (NOS) mRNA and protein. Furthermore, GT1–7 cells are NADPH‐diaphorase‐positive (a marker of NOS activity) and the histochemical reaction can be abolished by treatment with a competitive

Who reads Nitric Oxide Is Involved in the Genesis of Pulsatile LHRH Secretion from Immortalized LHRH Neurons?

Author

Francisco José López; Marcelo Moretto; István Merchenthaler; Andrés Negro-Vilar

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-8194)

Published

1997

Language

EN

Field

Neuroscience (Life Sciences)