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Genetic Factors and the Presence of Coronary Collaterals in Patients with Stable Coronary Artery Disease by E Kozlova; I Starostin; A Balatskyi; O Bulkina; V Lopukhova; U Karpov is a Medicine article available to read on EtoBox.

What is Genetic Factors and the Presence of Coronary Collaterals in Patients with Stable Coronary Artery Disease about?

## Abstract ## Background The coronary collateral circulation (CCC) varies in patients with coronary artery disease (CAD). Although many studies were provided to detect factors associated with collateral development, genetic factors are still studied insufficiently. The goal of this study was to assess the association of single nucleotide polymorphisms (SNP) in genes involved in vascular growth with CCC in patients with stable CAD. ## Purpose To assess if genetic variations in hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), urokinase-type plasminogen activator (gene PLAU) are associated with the presence of coronary collaterals in patients with stable CAD. ## Methods A single-centered study was performed between March 2012 and December 2017. In 579 patients with stable CAD who underwent coronary angiography and had at least 50% stenosis in at least one major coronary artery collaterals were assessed by the use of the Rentrop score (0–3) during coronary angiography. SNPs PLAU rs4065, VEGF rs1570360, rs2010963 and rs699947, HGF rs5745752 were genotyped, multivariate logistic regression was carried out to determine the association of genotypes with CCC. ## R

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Author

E Kozlova; I Starostin; A Balatskyi; O Bulkina; V Lopukhova; U Karpov

Publisher

Oxford University Press (OUP)

Published

2020

Language

EN

Field

Medicine (Health Sciences)