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1) Mannitol may be useful clinically as both a diuretic to treat edema and increase urine flow, as well as an extracellular solute to decrease cerebral edema and prevent cell swelling. 2) Mannitol is not absorbed orally so it must be given intravenously, where it distributes in the extracellular fluid and is excreted unchanged in urine. 3) As an osmotic diuretic, mannitol works by inhibiting sodium reabsorption in the proximal tubule and loop of Henle, increasing sodium delivery and excretion of calcium,

Author

kristiandiorcapili

Language

EN