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This research presents a novel fourth-generation CAR-T cell therapy, specifically CD19 CAR-T cells engineered to express membrane-bound interleukin-15 and CXCR5, aimed at improving treatment outcomes for B-cell lymphoma. The modified CAR-T cells demonstrated enhanced cytotoxicity, better tumor infiltration, and sustained antitumor effects compared to traditional CD19 CAR-T cells in both in vitro and in vivo models. Preliminary safety evaluations indicate that this approach is a promising and relatively safe

Author

hemdanihajar0

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EN