Can I read Additional Evidence That L-5-hydroxytryptophan Discrimination Models a Unique Serotonin Receptor on EtoBox?

Additional Evidence That L-5-hydroxytryptophan Discrimination Models a Unique Serotonin Receptor by Roberta Friedman; Robert J. Barrett; Elaine Sanders-Bush is a Neuroscience article available to read on EtoBox.

What is Additional Evidence That L-5-hydroxytryptophan Discrimination Models a Unique Serotonin Receptor about?

The purpose of the present studies was to investigate further the role of central serotonin (5-HT) in mediating the L-5-hydroxytryptophan (L-5-HTP) discriminative cue. Rats were trained to discriminate the stimulus properties of 35 mg/kg L-5-HTP combined with RO 4-4602, a peripheral decarboxylase inhibitor. Considering that several 5-HT antagonists were unable to block the L-5-HTP discriminative cue in our earlier studies, we extended these studies to include the two other presumed 5-HT antagonists mianserin and BC-105 (pizotyline). Only BC-105 completely blocked the training dose of L-5-HTP. Furthermore, the blockade of the L-5-HTP cue was both graded and surmountable by increasing the dose of L-5-HTP, suggesting a competitive antagonism. In neurochemical studies, the regional brain levels of 5-HT, norepinephrine and dopamine were determined after the injection of the training dose of L-5-HTP. Marked changes in the levels of 5-HT were found, while the levels of the catecholamines were changed only slightly or not at all. Furthermore, dose-response studies of L-5-HTP demonstrated an orderly dose-related increase in the levels of 5-HT in brain and in the percent responding on the L-

Who reads Additional Evidence That L-5-hydroxytryptophan Discrimination Models a Unique Serotonin Receptor?

Author

Roberta Friedman; Robert J. Barrett; Elaine Sanders-Bush

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0033-3158)

Published

1982

Language

EN

Field

Neuroscience (Life Sciences)