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Can I read Substituted uracil derivatives as potent inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1) on EtoBox?
Substituted uracil derivatives as potent inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1) by Henning Steinhagen; Michael Gerisch; Joachim Mittendorf; Karl-Heinz Schlemmer; Barbara Albrecht is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Substituted uracil derivatives as potent inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1) about?
A new class of PARP-1 inhibitors, namely substituted fused uracil derivatives were synthesised. Starting from a derivative with an IC(50)=2microM the chemical optimisation program led to compounds with more than a 100-fold increase in potency (IC(50)<20nM). Additionally, physicochemical and pharmacokinetic properties were evaluated. It could be shown that compounds bearing a piperazine or phenyl substituted betaAla-Gly side chain exhibited the best overall profile.
Who reads Substituted uracil derivatives as potent inhibitors of poly(ADP-ribose)polymerase-1 (PARP-1)?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Henning Steinhagen; Michael Gerisch; Joachim Mittendorf; Karl-Heinz Schlemmer; Barbara Albrecht
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2002
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)