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Simultaneous Determination of Vitamins b1, b2, b6, and Niacinamide in Multivitamin Pharmaceutical Preparations by Paired-ion Reversed-phase High-Pressure Liquid Chromatography by Roderic P. Kwok; W.P. Rose; Rick Tabor; Thomas S. Pattison is a Chemistry article available to read on EtoBox.

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A high-pressure liquid chromatographic procedure for the simultaneous determination of vitamins B1, B2, B6, and niacinamide in multivitamin pharmaceutical preparations was developed and evaluated. The method uses paired-ion reversed-phase partition chromatography for baseline separation of the four water-soluble vitamins. This method was applied to the analysis of a multivitamin and multivitamin-multimineral tablets, and a technique was developed to reduce vitamin adsorption by the minerals. The results obtained by this method were compared with those obtained by the official methods. It was concluded that this method is fast, accurate, specific, and suitable for routine quality control use.

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Author

Roderic P. Kwok; W.P. Rose; Rick Tabor; Thomas S. Pattison

Publisher

Elsevier BV

Published

1981

Language

EN

Field

Chemistry (Physical Sciences)