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Oral Iron Chelation and the Treatment of Iron Overload in a Pediatric Hematology Center by Jean L. Raphael; M. Brooke Bernhardt; Donald H. Mahoney; Brigitta U. Mueller is a Medicine article available to read on EtoBox.

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## Abstract ## Background Recent advances have led to the development of oral iron chelators, which have changed clinical practice. The objective of this study was to descriptively assess the use of one such agent, deferasirox, as standard of care treatment in a large pediatric hematology center. ## Procedure We retrospectively studied all patients at the Texas Children's Hematology Center who were previously or currently treated with deferasirox. We gathered data on demographics, clinical diagnoses, length of time on chronic transfusions, previous use of deferoxamine, adherence to therapy, and reasons for discontinuation. We also assessed changes in serum ferritin, liver function tests, and creatinine for those on deferasirox for a minimum of 12 months. ## Results Fifty‐nine patients were studied. Eighty‐one percent of patients treated with deferasirox had a diagnosis of sickle cell disease. The mean baseline ferritin level for our study population was 2,117 ng/ml (range 754–7,211). Fifty‐three percent of patients had been previously treated with deferoxamine. Adherence to oral therapy was documented in 76% of patients. For those on deferasirox for a minimum of 12 months, serum fe

Who reads Oral Iron Chelation and the Treatment of Iron Overload in a Pediatric Hematology Center?

Author

Jean L. Raphael; M. Brooke Bernhardt; Donald H. Mahoney; Brigitta U. Mueller

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1545-5009)

Published

2009

Language

EN

Field

Medicine (Health Sciences)