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Pharmacologic Suppression of Neuronal Oxidative Damage and Dendritic Degeneration Following Direct Activation of Glial Innate Immunity in Mouse Cerebrum by Dejan Milatovic; Snjeanna Zaja-Milatovic; Kathleen S. Montine; Philip J. Horner; Thomas J. Montine is a Neuroscience article available to read on EtoBox.
What is Pharmacologic Suppression of Neuronal Oxidative Damage and Dendritic Degeneration Following Direct Activation of Glial Innate Immunity in Mouse Cerebrum about?
## Abstract Activation of glial innate immunity is widely proposed to contribute to a number of degenerative and destructive diseases of brain. However, the precise role of activated innate immunity has been difficult to define __in vivo__ because of multiple simultaneous pathogenic processes and responses to injury that confound interpretation of results from complex models of disease. Here, we used the model of intracerebroventricular (ICV) injection of lipopolysaccharide (LPS) to test the hypothesis that directly activated glial innate immunity leads to neurodegeneration in cerebrum and to establish the molecular determinants of and neuroprotectants from such innate immunity‐mediated neuronal damage. Our results showed that ICV LPS induced delayed, reversible oxidative damage to cerebral neuronal membranes as measured by F~4~‐neuroprostanes that was coincident with degeneration of the hippocampal pyramidal neuron dendritic system, but not neuron death, in adult mice. Both neuronal oxidative damage and dendritic degeneration were NF‐κB and iNOS dependent and were completely suppressed by ibuprofen and α‐tocopherol, but not naproxen or γ‐tocopherol. These results prove that activa
Who reads Pharmacologic Suppression of Neuronal Oxidative Damage and Dendritic Degeneration Following Direct Activation of Glial Innate Immunity in Mouse Cerebrum?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Dejan Milatovic; Snjeanna Zaja-Milatovic; Kathleen S. Montine; Philip J. Horner; Thomas J. Montine
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 2003
- Language
- EN
- Field
- Neuroscience (Life Sciences)