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Multiple Time-Point 68Ga-PSMA I&T PET/CT for Characterization of Primary Prostate Cancer: Value of Early Dynamic and Delayed Imaging by Sebastian Schmuck; Martin Mamach; Florian Wilke; Christoph A. von Klot; Christoph Henkenberens; James T. Thackeray; Jan M. Sohns; Lilli Geworski; Tobias L. Ross; Hans-Juergen Wester; Hans Christiansen; Frank M. Bengel; Thorsten Derlin is a Medicine article available to read on EtoBox.
What is Multiple Time-Point 68Ga-PSMA I&T PET/CT for Characterization of Primary Prostate Cancer: Value of Early Dynamic and Delayed Imaging about?
## Purpose: The aims of this study were to gain mechanistic insights into prostate cancer biology using dynamic imaging and to evaluate the usefulness of multiple time-point ga-prostate-specific membrane antigen (psma) i&t pet/ct for the assessment of primary prostate cancer before prostatectomy. ## Methods: Twenty patients with prostate cancer underwent ga-psma i&t pet/ct before prostatectomy. the pet protocol consisted of early dynamic pelvic imaging, followed by static scans at 60 and 180 minutes postinjection (p.i.). suvs, time-activity curves, quantitative analysis based on a 2-tissue compartment model, patlak analysis, histopathology, and gleason grading were compared between prostate cancer and benign prostate gland. ## Results: Primary tumors were identified on both early dynamic and delayed imaging in 95% of patients. tracer uptake was significantly higher in prostate cancer compared with benign prostate tissue at any time point (p ≤ 0.0003) and increased over time. consequently, the tumor-to-nontumor ratio within the prostate gland improved over time (2.8 at 10 minutes vs 17.1 at 180 minutes p.i.). tracer uptake at both 60 and 180 minutes p.i. was significantly higher in
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- Author
- Sebastian Schmuck; Martin Mamach; Florian Wilke; Christoph A. von Klot; Christoph Henkenberens; James T. Thackeray; Jan M. Sohns; Lilli Geworski; Tobias L. Ross; Hans-Juergen Wester; Hans Christiansen; Frank M. Bengel; Thorsten Derlin
- Publisher
- Lippincott Williams and Wilkins; Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 0363-9762)
- Published
- 2017
- Language
- EN
- Field
- Medicine (Health Sciences)