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## Abstract ## Purpose The Women's Health Initiative (WHI) study that documented an unfavorable benefit to risk ratio of Prempro and subsequently an increased risk of stroke with menopausal estrogen prompted us to investigate the use during 1992 through June 2003 of menopausal hormones in the United States. ## Methods Two pharmaceutical research databases from IMS Health, the National Prescription Audit __Plus__TM and the National Disease and Therapeutic IndexTM, were accessed and analyzed. ## Results The number of dispensed outpatient prescriptions for oral menopausal estrogens and oral combination estrogen–progestins increased 2.5‐fold (153%) from 34.5 million dispensed in 1992 to a high of 87.3 million in 2000. For July 2002 through June 2003, the year following the publication of the results of the WHI trial, prescriptions for these products declined to 59.6 million, a 32% decrease from their peak in 2000. Prescriptions for transdermal estrogen and transdermal combination estrogen–progestin products increased from 5.2 million dispensed in 1992 to their peak of 8.3 million in 2000, and declined 10% to 7.5 million during July 2002 through June 2003. By contrast, prescriptions for

Who reads Use of menopausal hormones in the United States, 1992 through June, 2003?

Author

Diane K. Wysowski; Laura A. Governale

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1053-8569)

Published

2004

Language

EN

Field

Medicine (Health Sciences)