Can I read Dexamethasone Improves the Efficacy of Granisetron in the First 24 H Following High-dose Cisplatin Chemotherapy on EtoBox?
Dexamethasone Improves the Efficacy of Granisetron in the First 24 H Following High-dose Cisplatin Chemotherapy by Jean Latreille; Dave Stewart; Francis Laberge; Paul Hoskins; James Rusthoven; Elissa McMurtrie; David Warr; Louise Yelle; David Walde; Frances Shepherd; Harbhajan Dhaliwal; Brian Findlay; David Mee; Dianne Johnston is a Medicine article available to read on EtoBox.
What is Dexamethasone Improves the Efficacy of Granisetron in the First 24 H Following High-dose Cisplatin Chemotherapy about?
The object of the study was to determine whether dexamethasone improved the efficacy of the serotonin receptor (5-HT3) antagonist granisetron in controlling acute (within 24 h) emesis in cancer patients receiving high-dose cisplatin chemotherapy and to ascertain whether continuation of granisetron after 24 h reduces the occurrence of delayed emesis. This randomised, double-blind, multicentre, three-arm study was conducted at 21 medical centres. A group of 292 nausea- and emesis-free patients with cancer, who had never had chemotherapy and were scheduled to receive at least 50 mg/m2 cisplatin, were given 3 mg granisetron i.v. in a 15-min infusion with or without 10 mg dexamethasone i.v. completed 5 min prior to high-dose cisplatin and 1 mg granisetron p.o. at +6 h and +12 h. Primary study end-points were control of emesis and nausea. Patients completed a self-report diary every 6 h for the first 24 h. At the end of the 24-h period, the patients who received dexamethasone had a significantly higher complete protection rate from emesis (64% compared to 39%) than those who received no steroid. Similarly, the dexamethasone-treated group had a significantly higher complete plus partial (
Who reads Dexamethasone Improves the Efficacy of Granisetron in the First 24 H Following High-dose Cisplatin Chemotherapy?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Jean Latreille; Dave Stewart; Francis Laberge; Paul Hoskins; James Rusthoven; Elissa McMurtrie; David Warr; Louise Yelle; David Walde; Frances Shepherd; Harbhajan Dhaliwal; Brian Findlay; David Mee; Dianne Johnston
- Publisher
- Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 0941-4355)
- Published
- 1995
- Language
- EN
- Field
- Medicine (Health Sciences)