Can I read Model predicted Down syndrome detection rates for nuchal translucency screening in twin pregnancies on EtoBox?

Model predicted Down syndrome detection rates for nuchal translucency screening in twin pregnancies by Ron Maymon; Hadar Rosen; Ohad Baruchin; Arie Herman; Howard Cuckle is a Medicine article available to read on EtoBox.

What is Model predicted Down syndrome detection rates for nuchal translucency screening in twin pregnancies about?

## Abstract ## Objective To estimate the Down syndrome detection rate for nuchal translucency (NT) screening in twins when fetus‐specific risk allows for between‐fetus NT correlation. ## Methods The between‐fetus correlation coefficient of log NT, in multiples of the median (MoM), was estimated from a series of 977 unaffected twins scanned at a single centre. Results were expressed in multiples of the normal median using a curve derived from 515 unaffected singleton pregnancies at the same centre. A screening result was classified as positive if the risk for __at least one fetus__ exceeded the cut‐off. Detection rates were estimated for a fixed 1–5% false‐positive rate, at different gestational weeks, separately for risk calculation using an algorithm which takes account of between‐fetus NT correlation or not. ## Results The correlation coefficient in unaffected pregnancies was 0.43 (__P__ < 0.0001) and estimated to be 0.23 and 0.11 in discordant and concordant twins. At 12 weeks of gestation, the model predicted detection rate for a 3% false‐positive rate was 68% when between‐fetus correlation is not taken into account, increasing to 73% when it is applied. Similarly, for other fa

Who reads Model predicted Down syndrome detection rates for nuchal translucency screening in twin pregnancies?

Author

Ron Maymon; Hadar Rosen; Ohad Baruchin; Arie Herman; Howard Cuckle

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0197-3851)

Published

2011

Language

EN

Field

Medicine (Health Sciences)