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Noureldin et al. designed and synthesized benzimidazole-based thio-oxadiazole and thio-thiadiazole analogues as potential antimicrobial agents targeting phenylalanyl-tRNA synthetase (PheRS). Computational studies indicated that these compounds could effectively mimic the natural substrate Phe-AMP, and in vitro evaluations revealed compound 8b exhibited moderate activity against S. aureus with an MIC of 32 μg/mL. The findings suggest that compound 8b could serve as a lead for further development of high-affi

Author

kamir3230

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EN