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Can I read Intestinal immunity of Escherichia coli NISSLE 1917: a safe carrier for therapeutic molecules on EtoBox?
Intestinal immunity of Escherichia coli NISSLE 1917: a safe carrier for therapeutic molecules by Astrid M. Westendorf; Florian Gunzer; Stefanie Deppenmeier; Damini Tapadar; J. Katrin Hunger; M. Alexander Schmidt; Jan Buer; Dunja Bruder is a Medicine article available to read on EtoBox.
What is Intestinal immunity of Escherichia coli NISSLE 1917: a safe carrier for therapeutic molecules about?
The development of novel approaches that allow accurate targeting of therapeutics to the intestinal mucosa is a major task in the research on intestinal inflammation. For the first time, a live genetically modified bacterial strain has been approved by Dutch authorities as a therapeutic agent for experimental therapy of intestinal bowel disease (IBD) in humans. Genetically modified probiotics can very well be used as carriers for localized antigen delivery into the intestine. Therapeutic safety, however, of such a carrier organism, is crucial, especially when a specific probiotic strain has to be used under diseased conditions. In this study, we tested the potential of Escherichia coli NISSLE 1917 to serve as a safe carrier for targeted delivery of recombinant proteins to the intestinal mucosa. In a well-defined and very sensitive immunological system, we demonstrate that intestinal recombinant E. coli NISSLE 1917 has no effect on migration, clonal expansion and activation status of specific CD4 + T cells, neither in healthy mice nor in animals with acute colitis. Furthermore, recombinant E. coli NISSLE 1917 has no effect on the induction or breakdown of peripheral T-cell tolerance
Who reads Intestinal immunity of Escherichia coli NISSLE 1917: a safe carrier for therapeutic molecules?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Astrid M. Westendorf; Florian Gunzer; Stefanie Deppenmeier; Damini Tapadar; J. Katrin Hunger; M. Alexander Schmidt; Jan Buer; Dunja Bruder
- Publisher
- John Wiley and Sons; Oxford University Press; Wiley; Oxford University Press (OUP); Elsevier BV (ISSN 0928-8244)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Life Sciences)