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Validation of traditional claims of anti-arthritic efficacy of trans-Himalayan snow mountain garlic (Allium ampeloprasum L.) extract using adjuvant-induced arthritis rat model: A comparative evaluation with normal garlic (Allium sativum L.) and dexamethasone by Bhupinder Kaur; Nitish Kumar; Manoj K. Patel; Kanwaljit Chopra; Shweta Saxena is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Validation of traditional claims of anti-arthritic efficacy of trans-Himalayan snow mountain garlic (Allium ampeloprasum L.) extract using adjuvant-induced arthritis rat model: A comparative evaluation with normal garlic (Allium sativum L.) and dexamethasone about?

## Ethnopharmacological relevance: Snow mountain garlic (smg) (allium ampeloprasum l.) is a wild trans-himalayan member of the genus allium, valued for its anti-inflammatory and anti-arthritic properties in the mountain folk medicinal system (sowa-rigpa). despite its age-old medicinal usage by traditional therapists and the native population for various ailments including rheumatism, there is no scientific validation of its phyto-pharmaceutical merits. ## Aim of the study: The present pre-clinical study compared the in-vivo anti-arthritic effects of smg with reported efficacy doses of normal garlic (allium sativum l.) extract and dexamethasone in a complete freund's adjuvant (cfa)-induced arthritis rat model. ## Materials and methods: The female wistar rats were immunized by the subplannter injection of cfa into the right hind footpad. aqueous extracts of smg and normal garlic were administered orally at a dose of 250 mg/kg and 500 mg/kg for 28 days. dexamethasone was used as positive control drug. behavioral parameters including paw markers, arthritis index, joint stiffness, body weight change, etc. were measured. also, the changes in histopathological indices, hematological profi

Who reads Validation of traditional claims of anti-arthritic efficacy of trans-Himalayan snow mountain garlic (Allium ampeloprasum L.) extract using adjuvant-induced arthritis rat model: A comparative evaluation with normal garlic (Allium sativum L.) and dexamethasone?

Author

Bhupinder Kaur; Nitish Kumar; Manoj K. Patel; Kanwaljit Chopra; Shweta Saxena

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)