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Pulmonary Toxicities of Molecular Targeted Antineoplastic Agents: a Single-center 10-Year Experience by Min-Young Lee; Seug Yun Yoon; Kyoung Ha Kim; Namsu Lee; Ha Youn Kim; Jung Hwa Hwang; Jong-Ho Won is a Medicine article available to read on EtoBox.

What is Pulmonary Toxicities of Molecular Targeted Antineoplastic Agents: a Single-center 10-Year Experience about?

## Background/Aims A better understanding of cancer cell biology has led to the discovery and development of several new targeted agents for cancer. These drugs are widely used in cancer treatment and have good toxicity profiles. However, some patients are extremely sensitive to these drugs and can develop severe toxicities. Among the toxicities, pulmonary complications are infrequent with most targeted therapies. This study aimed to identify the radiologic pulmonary complications in various targeted therapies and to analyze the characteristics of patients with pulmonary toxicity. ## Methods We retrospectively reviewed the medical records and chest image findings of 644 patients who were treated with targeted antineoplastic agents at Soonchunhyang University Hospital between May 2005 and September 2014. ## Results Of these 644 patients, 90 (14.0%) developed pulmonary complications as noted on chest computed tomography. Among these patients, 15 (2.3%) developed drug-related pulmonary toxicities. Treatment with targeted agents was discontinued in all patients, while 11 patients were simultaneously treated with glucocorticoids. Three patients died of drug-related pulmonary toxicity. #

Who reads Pulmonary Toxicities of Molecular Targeted Antineoplastic Agents: a Single-center 10-Year Experience?

Author

Min-Young Lee; Seug Yun Yoon; Kyoung Ha Kim; Namsu Lee; Ha Youn Kim; Jung Hwa Hwang; Jong-Ho Won

Publisher

Korean Association of Internal Medicine

Published

2021

Language

EN

Field

Medicine (Health Sciences)