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Racial variation in the O-acetylation phenotype of human colonic mucosa by Fiona Campbell; Mark A. C. Appleton; Clare E. Fuller; Michael P. Greeff; Jonas Hallgrimsson; Ryohei Katoh; O. L. Irene Ng; Ali Satir; Geraint T. Williams; Professor Sir E. Dillwyn Williams is a Medicine article available to read on EtoBox.
What is Racial variation in the O-acetylation phenotype of human colonic mucosa about?
## Abstract __O__‐acetylated and non‐__O__‐acetylated sialoglycoproteins can be distinguished by the mPAS (mild periodic acid‐Schiff) histochemical technique. Individual adults show one of three different patterns of staining of large intestinal mucosa: uniformly mPAS‐positive, uniformly mPAS‐negative, or mPAS‐negative with scattered mPAS‐positive crypts. To test our hypothesis that these variations are the results of a single autosomal gene (__oat__) polymorphism, we have studied the frequency of the three patterns of staining in a total of 435 adult colon specimens from six geographically separate populations: British, South African blacks, Icelanders, Japanese, Hong Kong Chinese, and Bahrainis. The distribution of the three types of staining fell into two groups. In Japanese and Chinese, uniformly mPAS‐positive cases were much more frequent than uniformly mPAS‐negative cases; this distribution differed significantly (__X__^2^, __P__<0·001) from that in non‐Sino‐Japanese, where the uniformly mPAS‐positive phenotype was much less frequently found than the uniformly mPAS‐negative phenotype. In neither of the groups did the frequency of the three phenotypes differ significantly from
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- Author
- Fiona Campbell; Mark A. C. Appleton; Clare E. Fuller; Michael P. Greeff; Jonas Hallgrimsson; Ryohei Katoh; O. L. Irene Ng; Ali Satir; Geraint T. Williams; Professor Sir E. Dillwyn Williams
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)
- Published
- 1994
- Language
- EN
- Field
- Medicine (Health Sciences)