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Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group by Siritron Samosorn; Bongkot Tanwirat; Nussara Muhamad; Gabriele Casadei; Danuta Tomkiewicz; Kim Lewis; Apichart Suksamrarn; Therdsak Prammananan; Karina C. Gornall; Jennifer L. Beck; John B. Bremner is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group about?
Conjugation of the NorA substrate berberine and the NorA inhibitor 5-nitro-2-phenyl-1H-indole via a methylene ether linking group gave the 13-substituted berberine-NorA inhibitor hybrid, 3. A series of simpler arylmethyl ether hybrid structures were also synthesized. The hybrid 3 showed excellent antibacterial activity (MIC Staphylococcus aureus, 1.7 microM), which was over 382-fold more active than the parent antibacterial berberine, against this bacterium. This compound was also shown to block the NorA efflux pump in S. aureus.
Who reads Antibacterial activity of berberine-NorA pump inhibitor hybrids with a methylene ether linking group?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Siritron Samosorn; Bongkot Tanwirat; Nussara Muhamad; Gabriele Casadei; Danuta Tomkiewicz; Kim Lewis; Apichart Suksamrarn; Therdsak Prammananan; Karina C. Gornall; Jennifer L. Beck; John B. Bremner
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)