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Can I read Biodegradable Dual-Function Nanocomposite Hydrogels for Prevention of Bisphosphonate-Related Osteonecrosis of the Jaw on EtoBox?

Biodegradable Dual-Function Nanocomposite Hydrogels for Prevention of Bisphosphonate-Related Osteonecrosis of the Jaw by Thavornyutikarn, Boonlom (author);Sungkhaphan, Piyarat (author);Kaewkong, Pakkanun (author);Pornsuwan, Soraya (author);Risangud, Nuttapol (author);Singhatanadgit, Weerachai (author);Janvikul, Wanida (author) is a Materials Science article available to read on EtoBox.

What is Biodegradable Dual-Function Nanocomposite Hydrogels for Prevention of Bisphosphonate-Related Osteonecrosis of the Jaw about?

This study presents the development of composite hydrogels, comprising a biodegradable polymer (carboxymethyl chitosan (CMCS or CM)) and a mixture of plasma-treated mesoporous silica nanoparticles (PMCM-41 or PM) and aminefunctionalized mesoporous silica nanoparticles (NMCM-41 or NM), coloaded with a hydrophilic antibiotic (clindamycin hydrochloride (CDM or C)) and a poorly water-soluble compound (geranylgeraniol (GGOH or G)) for prevention of bisphosphonate-related osteonecrosis of the jaw (BRONJ). The CG-loaded hydrogel stabilities were better maintained when CDMpreloaded PMCM-41 and NMCM-41 were initially used and governed by weight ratios of CDM-loaded PMCM-41 to NMCM-41 and CDM quantity utilized. 5PM240C-1NM-CM demonstrated the best CDM-loaded hydrogel for GGOH postloading. The scanning electron microscopy (SEM) and X-ray microcomputer-tomography (μCT) images of 5PM240C-1NM-CM revealed a porous structure with homogeneously distributed nanoparticles. Two GGOH-loaded 5PM240C-1NM-CM hydrogels were generated after GGOH loadings. Their biphasic drug release profiles were fitted by Ritger−Peppas and Hixson−Crowell models. The copresence of GGOH could hinder CDM releases, while GGOH

Who reads Biodegradable Dual-Function Nanocomposite Hydrogels for Prevention of Bisphosphonate-Related Osteonecrosis of the Jaw?

It is typically read by researchers, students, and practitioners in Materials Science.

Author
Thavornyutikarn, Boonlom (author);Sungkhaphan, Piyarat (author);Kaewkong, Pakkanun (author);Pornsuwan, Soraya (author);Risangud, Nuttapol (author);Singhatanadgit, Weerachai (author);Janvikul, Wanida (author)
Publisher
American Chemical Society (ACS)
Published
2023
Language
EN
Field
Materials Science (Physical Sciences)

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