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0714 Weight Loss in Patients Prescribed Methadone for Restless Legs Syndrome by John Winkelman; Adysn Kilty is a Psychology article available to read on EtoBox.

What is 0714 Weight Loss in Patients Prescribed Methadone for Restless Legs Syndrome about?

## Abstract ## Introduction Weight loss is an underexplored side effect of methadone. While methadone is associated with weight gain when used to treat opioid use disorder, its impact on patients with restless legs syndrome (RLS) remains unclear. This study aims to assess the prevalence of significant weight loss in RLS patients prescribed methadone. ## Methods 73 consecutive patients for whom at least 6 months of follow-up was available following initiation of methadone for RLS and who were not undergoing weight loss interventions were assessed. Clinical information was extracted from the initial visit and all subsequent visits conducted throughout the course of methadone treatment (mean duration=2.9 years). Examination of associations with weight loss >10% and >20% of body weight within the first 6 months of methadone initiation was performed. ## Results In the 73 patients, the mean age was 67.6, mean BMI=29.3 and 51.4% were female. At methadone initiation, 18.1% were taking dopamine agonists (DA), 30.6% alpha-2-delta calcium channel ligands (A2D), and 38.9% both DAs and A2Ds. Notably, 19.4% of patients experienced weight loss >10%, and 6.9% lost >20% of their body weight. Those

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Author

John Winkelman; Adysn Kilty

Publisher

Oxford University Press (OUP)

Published

2024

Language

EN

Field

Psychology (Health Sciences)