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Can I read LigAlign: Flexible ligand-based active site alignment and analysis on EtoBox?
LigAlign: Flexible ligand-based active site alignment and analysis by Abraham Heifets; Ryan H. Lilien is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is LigAlign: Flexible ligand-based active site alignment and analysis about?
Ligand-based active site alignment is a widely adopted technique for the structural analysis of protein-ligand complexes. However, existing tools for ligand alignment treat the ligands as rigid objects even though most biological ligands are flexible. We present LigAlign, an automated system for flexible ligand alignment and analysis. When performing rigid alignments, LigAlign produces results consistent with manually annotated structural motifs. In performing flexible alignments, LigAlign automatically produces biochemically reasonable ligand fragmentations and subsequently identifies conserved structural motifs that are not detected by rigid alignment.
Who reads LigAlign: Flexible ligand-based active site alignment and analysis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Abraham Heifets; Ryan H. Lilien
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1093-3263)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Physical Sciences)